28 Aug 2017


Dietary Supplements and Health: The Essence of Bioavailability

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This white paper explores the critical relationship between dietary supplements and bioavailability, emphasizing the impact of bioavailability on the efficacy of xenobiotics, including pharmaceuticals and dietary supplements. The paper outlines the role of dietary supplements in addressing nutritional deficits during illness, malnutrition, or intense physical exercise. It delves into the complex journey of xenobiotics through the gastrointestinal tract, liver, and other physiological barriers, elucidating the challenges these compounds face before reaching their target sites.

The discussion on pharmacokinetics and pharmacodynamics highlights the interconnectedness between a xenobiotic’s metabolic fate and its therapeutic effects. The paper underscores the importance of bioavailability as the ultimate outcome of pharmacokinetic processes and its contextual relevance to different health conditions. Practical considerations regarding bioavailability are discussed, using curcumin as an example, emphasizing the need to assess bioavailability in the specific context of the intended therapeutic use.

The paper concludes by advocating for personalized measurements of bioavailability to gauge the pharmacodynamic potential of xenobiotics. It suggests that scientific methodologies used for drug evaluation should be extended to dietary supplements, offering insights into their efficacy and encouraging evidence-based practices in the dietary supplement market.